Cyclic GMP-AMP (cGAMP) synthase (cGAS), a sensor of cytosolic DNA, recognizes cytoplasmic nucleic acids to activate the innate immune responses via generation of the second messenger cGAMP and subsequent activation of the stimulator of interferon genes (STINGs).The cGAS-STING IMMUNO-MULTI signaling has multiple immunologic and physiological functio
Nitrogen can greatly influence the structure and productivity of microbial communities through its relative availability and form.However, roles of specific organisms in the uptake of different nitrogen species remain poorly characterized.Most studies seeking to identify agents of assimilation have been correlative, indirectly linking activity meas
The occurrence of an adverse drug event (ADE) has become a serious social concern of public health.Early detection of ADEs can lower the risk of drug safety as well as the expense DC Output of the drug.While post-market spontaneous reports of ADEs remain a cornerstone of pharmacovigilance, most existing signal detection algorithms rely on substanti
Recent studies have documented the presence of Niemann-Pick C1-Like 1 (NPC1L1) in the small intestine and its capacity to transport cholesterol in mice and rats.The current investigation was undertaken to explore the Bondage and Fetish localization and function of NPC1L1 in human enterocytes.Cell fractionation experiments revealed an NPC1L1 associa
Background: Cuproptosis is a novel form of cellular demise that occurs through a unique pathway involving lipoylated proteins in the tricarboxylic acid (TCA) cycle and is closely linked to mitochondrial metabolism.Nevertheless, the comprehensive elucidation of the impact of carcinogenesis-associated genes (CRGs) on prognosis, tumor microenvironment